Cdkn2a-interacting protein
WebThe CDKN2A gene mutations found in melanoma result in a nonfunctional p16(INK4A) protein. In many cases, a second, somatic mutation occurs in the normal copy of the … WebApr 12, 2024 · Methods and results: Directed differentiation of human pluripotent stem cells (hPSCs) into cardiomyocytes revealed that RB1 and CDKN2a are upregulated at the …
Cdkn2a-interacting protein
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WebCDKN2A MDM2. Affinity Capture-Western. Affinity Capture-Western. An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. WebUsing p19(ARF) (CDKN2A; 600160) as bait in a yeast 2-hybrid screen of a human testis cDNA library, Hasan et al. (2002) cloned CDKN2AIP, which they designated CARF. The deduced 580-amino acid protein is serine rich (21%) and has a calculated molecular mass of 61 kD. In human, mouse, and monkey cells, CARF localized to the nucleoplasm and …
WebMay 25, 2024 · CDKN2A interacting protein (CDKN2AIP) has previously been identified as a tumor suppressor in multiple malignant diseases. In this study, we aimed to further … WebFUNCTION: Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein. ... S80650 - Mus sp. P19 ARF protein (Cdkn2a) mRNA, complete cds.
WebPR:000005276 CDKN2A-interacting protein (term hierarchy) InterPro Domains. IPR014720 Double-stranded RNA-binding domain. IPR021859 XRN2-binding (XTBD) domain. Molecular Reagents less. All nucleic 35. cDNA 34. Primer pair 1. Microarray probesets 6. Other Accession IDs less. MGI:2142775 References more. WebBioGRID Interaction 635224 Between NPM1 And CDKN2A. An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag.
WebDec 23, 2024 · The interacting genes from the protein-protein interaction network and common immune checkpoint genes were used to analyze the relationship with CDKN2A. The results indicated that several immune checkpoint genes and the genes from the PPI network were correlated with CDKN2A expression levels in many tumors ( Figure 7B ).
WebMar 26, 2024 · (E,F) Show the protein–protein interaction network of PDHA1 and CDKN2A. interaction network diagram. ... (CDKN2A) is a protein-encoded gene and diseases associated with CDKN2A include melanoma, ... byers outlookWebJun 27, 2024 · Purpose The current study aims to explore the effects of CDKN2A on cell proliferation and cycle, and investigate the underlying mechanisms. Methods Expression of CDKN2A in cervical cancer cell lines was evaluated by real-time quantitative PCR (RT-qPCR) and western blotting. Apoptotic rate was detected by Annexin V assay. MTT … byers optometryWebMay 25, 2024 · CDKN2A interacting protein (CDKN2AIP) has previously been identified as a tumor suppressor in multiple malignant diseases. In this study, we aimed to further explore its role in testicular seminoma as well as the underlying molecular mechanisms. Retrospective testicular seminoma clinical samples, normal tissues, NTERA-2 cell line, … byers orillia polarisWebCDKN2A interacting protein: Gene name i. CDKN2AIP (CARF, FLJ20036) Protein class i. Number of transcripts i. 3: Protein evidence: Evidence at protein level ... The protein encoded by this gene regulates the DNA damage response through several different signaling pathways. One suc h pathway is the p53-HDM2-p21(WAF1) pathway, which is … byers organic gelWebApr 14, 2024 · The use of tobacco products is one of the established contributors toward the development and spread of oral cancer. Additionally, recent research has indicated oral microbiome, infections with Human papilloma virus (HPV), Epstein–Barr virus (EBV), Candida as significant contributing factors to this disease along with lifestyle habits. … byers outdoor advertisingWebFeb 9, 2024 · We demonstrate that in the uremic milieu, increased arterial expression of CDKN2A/p16INK4a associated with vascular progeria in CKD, independently of chronological age. The arterial expression of CDKN2A/p16INK4a was significantly higher in patients with coronary calcification (p=0.01) and associated cardiovascular disease … byers park and recreation districtp16 (also known as p16 , cyclin-dependent kinase inhibitor 2A, CDKN2A, multiple tumor suppressor 1 and numerous other synonyms), is a protein that slows cell division by slowing the progression of the cell cycle from the G1 phase to the S phase, thereby acting as a tumor suppressor. It is encoded by the CDKN2A gene. A deletion (the omission of a part of the DNA sequence during r… byers owen sound