Cisplatin pk
WebApr 14, 2024 · Moreover, in cisplatin-induced renal injury models, they also reduced serum blood urea nitrogen (BUN) and creatinine levels to different degrees, the best of which was 6-methylflavone. The pharmacophore model clarified that the aromatic ring, hydrogen bond acceptors, and hydrogen bond donors might play a vital role in the inhibitory effect of ... WebNov 18, 2024 · Individual pharmacokinetics (PK) parameters of Cisplatin were identified using a Bayesian approach. Nephrotoxicity and ototoxicity were considered as typical Cisplatin-related toxicities according to Common Terminology Criteria for Adverse Events (CTCAE) standards.
Cisplatin pk
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WebAug 20, 2024 · Population pharmacokinetic (PK) models for cisplatin are usually one- or two-compartment models and BSA is typically reported as a significant covariate … WebCisplatin for injection is indicated for the treatment of advanced bladder cancer. 2 DOSAGE AND ADMINISTRATION . 2.1 Hydration and Anti-Emetic Treatment . Patients treated …
WebJun 21, 2024 · Sodium Thiosulfate for Protection from Cisplatin-Induced Hearing Loss The addition of sodium thiosulfate, administered 6 hours after cisplatin chemotherapy, resulted in a lower incidence of cisplatin-induced hearing loss among children with standard-risk hepatoblastoma, without jeopardizing overall or event-free survival. WebCisplatin, a commonly used chemotherapeutic agent, is nephrotoxic. The mechanism by which cisplatin selectively kills the proximal tubule cells was heretofore unknown.
WebWe aimed to evaluate cisplatin pharmacokinetics (PK) and the exposure to unbound cisplatin in SCLC patients using the informative priors, and assess the relationship between the cisplatin... WebCisplatin, a class of platinum-containing anticancer drugs for the treatment of solid tumors, is a substrate of OCT2 and MATE1/MATE2-K. OCT2 is expressed in the basolateral …
WebFor intraperitoneal therapy, paclitaxel or cisplatin was reconstituted in 2 liters of warmed normal saline and infused as rapidly as possible through an implantable peritoneal catheter....
WebMar 1, 1998 · Although cisplatin has been used extensively for the treatment of solid tumors, the best administration schedule has not been decided yet. The majority of … the society for collegiate leadership cordsWebThe pharmacokinetics of platinum (Pt) and cisplatin (CDDP)-DNA adducts were studied in nude mice after single-dose CDDP treatments. Whole blood, serum, kidney, lever, testis, brain, and tumor were collected at different intervals after injection of … the society explainedWebMar 1, 2024 · Cisplatin (Platinol ®) is a chemotherapeutic agent, first approved by the U.S. Food and Drug Administration (FDA) in 1978 for the treatment of ovarian cancer and finds its use nowadays for the treatment of various types of cancer including cervical cancer, testicular cancer and germ cell tumors [1]. myrbetriq for urinary frequencyWebDec 31, 2008 · The cisplatin dose was 75 mg/m 2 for all cohorts and the pemetrexed dose was increased in increments of 100 mg/m 2 for subsequent cohorts. Treatment and dose escalation scheme. Pemetrexed and cisplatin were administered on day 1 of a 21-d cycle as i.v. infusions of 10 and 60 min, respectively. the society final explicadoWebOct 7, 2024 · In addition, significant immune cell infiltration was observed in the kidney after four doses of 9 mg/kg cisplatin, contrary to what has been previously reported. These … myrbetriq highest doseWebJun 15, 1987 · The plasma clearance of free cisplatin (26.1 ml/min/kg) was significantly greater than that of either Carboplatin (10.3 ml/min/kg) or insulin (10.1 ml/min/kg). The main route of excretion of the two platinum complexes was via the urine, with 80-90% of Carboplatin and 43-48% of cisplatin being excreted within 4 hr. myrbetriq formulationsWebAdministration of a nephrotoxic drug such as cisplatin can be used to cause renal dysfunction as an approach to mimic human serum levels of renally excreted drugs. We aimed to determine the dose of cisplatin that did not affect the survival rate of mice and to achieve human-like serum concentrations of cefepime. myrbetriq generic release date