The EP300 gene is located on the long (q) arm of the human chromosome 22 at position 13.2. This gene encodes the adenovirus E1A -associated cellular p300 transcriptional co-activator protein. EP300 is closely related to another gene, CREB binding protein, which is found on human chromosome 16 . See more Histone acetyltransferase p300 also known as p300 HAT or E1A-associated protein p300 (where E1A = adenovirus early region 1A) also known as EP300 or p300 is an enzyme that, in humans, is encoded by the … See more p300 HAT functions as histone acetyltransferase that regulates transcription via chromatin remodeling, and is important in the processes of cell proliferation and … See more Mutations in the EP300 gene are responsible for a small percentage of cases of Rubinstein-Taybi syndrome. These mutations result in the loss of one copy of the gene in … See more • GeneReviews/NCBI/NIH/UW entry on Rubinstein-Taybi Syndrome • GeneCard • EP300+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) See more The p300 protein carries out its function of activating transcription by binding to transcription factors, and the transcription machinery. On the … See more EP300 has been shown to interact with: • BCL3, • BRCA1, • CDX2, See more • Condorelli G, Giordano A (1998). "Synergistic role of E1A-binding proteins and tissue-specific transcription factors in differentiation". J. Cell. Biochem. 67 (4): 423–31. See more WebIn this report, immunoprecipitation with p300 antibodies reveals the presence of the pRB family proteins in p300 complexes when E1A is expressed in host cells, indicating that …
Ep300 E1A binding protein p300 [ Mus musculus (house mouse) ]
WebIn order to activate transcription of target A3A and A3B genes, we utilized a previously established CRISPR-activation (CRISPRa) system based on a dCas9 protein, a nucleolytically dead Cas9 protein harboring point mutations in RuvC and HNH domains, which is fused to a p300 core, a catalytic histone acetyltransferase core domain of the … WebMar 7, 2000 · We show that the same classes of proteins, RB and p300, involved in E1A-mediated transformation are also responsible for induction of apoptosis by E1A in a system that lacks p53. Our data... rifampin can you crush
Daniel Pinto - Lead Scientist - Walter Reed Army Institute
Web动物细胞培养的条件. 一般来说， 人高分化结肠腺癌细胞系 thc-8307细胞 体外培养需要满足以下条件 1 、无菌、无毒的环境：首先应保证被培养的细胞处于无菌、无毒的环境，即对培养液和所有的培养用具进行无菌处理。 通常还要在培养液中添加一定量的抗生素以防培养过 … WebE1A binding protein p300 Synonyms: KAT3B, RSTS2, p300 Species: Human EP300 (2033), Mouse Ep300 (328572), Rat Ep300 (170915), chicken... Summary: This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator... Related Products: Antibodies miRNA Mimics Proteins shRNA Panels esiRNA shRNA siRNA See … WebDescription. EP300, or E1A binding protein p300, functions as a histone acetyltransferase and regulates transcription via chromatin remodeling. EP300 is important in the processes of cell proliferation and differentiation, and also functions as acetyltransferase for nonhistone targets. EP300 mediates cAMP-gene regulation by binding specifically ... rifampin clearance