WebMar 14, 2024 · Genome-wide association studies (GWAS) of alcohol consumption have found few consistently replicable loci outside of the alcohol-metabolizing genes. A GWAS of alcohol consumption comprising 47,501 individuals of European ancestry found rs6943555 in AUTS2 to be associated with alcohol consumption13. This locus did not WebOct 19, 2024 · total score and alcohol dependence (r g=0.08; p=0.65) (13). In this study, we performed a GWAS meta-analysis us-ing the UK Biobank cohort (N=121,604) and the previously published 23andMe cohort (N=20,328) (10), yielding the largest GWAS meta-analysis of AUDIT total score to date (N=141,932). Using only the UK Biobank cohort, …
Genetically determined tobacco and alcohol use and risk of atrial ...
WebAWS severity was recorded using the Glasgow Modified Alcohol Withdrawal Score (GMAWS). The primary outcome measure was 15% change in erythrocyte transketolase … The MVP is an observational cohort study and biobank supported by the U.S. Department of Veterans Affairs (VA). Phenotypic data were collected from MVP participants using questionnaires and the VA EHR and a blood sample was obtained for genetic analysis. Ethics statement: The Central Veterans Affairs … See more AUDIT-C scores and AUD diagnostic codes were obtained from the VA EHR. The AUDIT-C comprises the first three items of the AUDIT and measures typical quantity (item 1) and frequency (item 2) of drinking and … See more MVP GWAS genotyping was performed using an Affymetrix Axiom Biobank Array with 686,693 markers. Subjects or SNPs with genotype call rate <0.9 or high heterozygosity were removed, leaving 353,948 subjects … See more Individuals <22 or > 90 years old and those with missing AUDIT-C scores were removed from the analyses, leaving 200,680 EAs; 56,495 … See more To differentiate population groups, we performed principal components analysis (PCA) using common SNPs (MAF > 0.05) shared in MVP [pruned using linkage disequilibrium (LD) of … See more ftb university shaders
Identifying and Reducing Bias in Genome-Wide Association …
WebTobacco and alcohol use are leading causes of mortality that influence risk for many complex diseases and disorders 1.They are heritable 2,3 and etiologically related 4,5 behaviors that have been resistant to gene discovery efforts 6–11.In sample sizes up to 1.2 million individuals, we discovered 566 genetic variants in 406 loci associated with … WebOct 27, 2024 · Manhattan Plot of Maximum Habitual Alcohol Intake GWAS in 247 755 Individuals of African and European Ancestry. ... LD score regression (LDSC) 18 was used to estimate SNV-heritability (h 2 SNV) and to characterize genetic correlations (r g) with a set of alcohol, psychiatric, and medical traits. WebMay 25, 2024 · Some of the novel variants (10 of 19) identified in this study were also associated with other alcohol-related traits, including AUDIT-C score 3, total AUDIT … giga is 10 to the power of