WebJul 1, 2005 · In solitary CHRPE, hypertrophic RPE cells with hyperpigmention have been reported. 5– 8 Additional findings have included presence of macromelanosomes 7 and absence of lipofuscin. 8 In contrast, the grouped CHPRE is composed of normal sized RPE cells with hyperpigmentation. 9 The CHRPE-like lesions seen in Gardner’s syndrome show … WebMar 9, 2024 · Solitary-Type Congenital Hypertrophy of the Retinal Pigment Epithelium (CHRPE) Solitary-type CHRPEs are well-demarcated, slightly elevated, gray-brown to …
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WebDec 1, 2007 · The term 'congenital hypertrophy of retinal pigment epithelium' or CHRPE was first coined by Buettner in 1975 to describe a solitary flat, pigmented, round lesion with sharply demarcated margins ... WebVirtually all patients with solitary CHRPE or GPR are asymptomatic, and lesions are benign; they are not associated with an increased risk of systemic disease. The prognosis is very good. Although rare (2%), there is evidence of benign (adenoma) or malignant (adenocarcinoma) transformation of RPE cells within solitary CHRPE lesions. tow ball sizes australia
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WebMost solitary CHRPE lesions have a typical depigmented ring or “halo” around the margin. The lacunae show enlargement in 32% of cases after a mean follow-up of 5 years. The … WebGass classified focal congenital anomalies of the RPE and proposed to call CHRPE “solitary melanotic nevi of the retinal pigment epithelium.” 1 Although some of the fundus lesions … Web(Figure 2e). A diagnosis of solitary CHRPE was made and we requested him annual review to document future morphological changes in the lesion. Case 3 Multiple small (2 mm), flat, pigmented lesions located in the inferior quadrant were seen in a 14-year-old girl. These lesions were arranged in a pair with the lesion size gradually powdered egg mixture comod